Sensitive Dependence of Mental Function on Prefrontal Cortex - Medcrave

Compelling data suggest higher mental functions, executive function, awareness, consciousness, planning, strategic thinking, imagination and processing sensory input are the domain of prefrontal cortex function and in particular Brodman areas 8, 9, 10, 46 [1,2]. Recent studies have also suggested that the mediating influence of prefrontal cortex function is crucial in depression and in antidepressant strategies [3] is it possible that what is true for depression may also be true for other psychiatric disorders? And if this is true, does that suggest that prefrontal cortex is endowed with a unique mediating influence of mood, normalcy and psychiatric illness? And does this suggest that a small decline of prefrontal cortex influence may have large effects in brain function and human behavior similar to the butterfly effect of complex systems?

Method

This paper will review diverse examples of the mediating influence of prefrontal cortex in normalcy and mental illness. Observations consistent with natural laws in support of them ediating prefrontal cortex influence will be presented (Table 1). Examples of diverse correlations between mental disorders and decline of prefrontal cortex will also be shown under the following headings:

I. Phylogeny

II. Biology

III. Clinical observations

IV. Neuroimaging studies

Phylogeny supports the mediating influence of

prefrontal cortex function

The idea that a brain region may enjoy greater influence over nervous system is partly rooted in natural observations consistent with the biological hierarchy of diverse living organisms [4-7] (Figure 1). A simple example is a logical one: head rules body and tail. A second example is an extension of the first. Brain rules peripheral nervous system. Of course head and body, brain and peripheral nervous system relationships are complex and bidirectional within the biological hierarchy of influence.

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